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- 1 George Clayton [1] b. 1781 d. Y
- Elizabeth Broaddus Gaines d. Y
- 2 Milton E. Clayton [1.1] b. Dec 23, 1800 d. Apr 09, 1885
- Caroline Erwin Hunter b. Jul 31, 1811 d. Feb 03, 1888
- 3 James Richard Clayton [1.1.1] b. 1830 d. May 02, 1902
- 3 Mary Elizabeth Clayton [1.1.2] b. 1831 d. 1913
- 3 Augustus Samuel Clayton, M.D. [1.1.3] b. Mar 20, 1832 d. May 05, 1927
- Frances Martha Hudson b. Mar 18, 1847 d. Aug 31, 1899
- 4 Lena Clayton [1.1.3.1] b. Mar 12, 1877 d. Y
- 4 Bertie Clayton [1.1.3.2] b. Jul 04, 1878 d. Y
- 4 Margaret Clayton [1.1.3.3] b. Aug 18, 1879 d. Y
- 4 Virginia Milton Clayton [1.1.3.4] b. Mar 03, 1881 d. Nov 14, 1953
- 4 Frances Leona Clayton [1.1.3.5] b. Nov 18, 1882 d. Jun 14, 1970
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- 4 Samuel R. Clayton [1.1.3.6] b. Nov 09, 1884 d. Y
- 4 Sallie Bernice Clayton [1.1.3.7] b. Jan 16, 1888 d. May 10, 1916
- 4 John Rowe Clayton [1.1.3.8] b. May 24, 1889 d. Aug 10, 1938
- 3 Adaline A. Clayton [1.1.4] b. Apr 27, 1835 d. Jul 24, 1891
- 3 Sarah Ann Clayton [1.1.5] b. Jul 13, 1837 d. Jul 12, 1906
- 3 Julia Caroline Clayton [1.1.6] b. Jan 05, 1841 d. Apr 23, 1921
- 3 Virginia Milton Clayton [1.1.7] b. Feb 27, 1843 d. Feb 14, 1907
- 2 Samuel Thomas Clayton [1.2] d. Y